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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Title Abbreviation

Mutat Res

ISSN

0027-5107

Electronic ISSN

1873-135X

Therapeutic Area

Biology, Biotechnology, Genomics, Molecular Medicine, Physiology, Research, Toxicology

Readership

Biologists, Cell Biologists, Epidemiologists, Microbiologists, Molecular Biologists, Researchers, Scientists, Toxicologists

Scope

Mutation Research provides a platform for publishing all aspects of DNA mutations and epimutations, from basic evolutionary aspects to translational applications in genetic and epigenetic diagnostics and therapy. Mutations are defined as all possible alterations in DNA sequence and sequence organization, from point mutations to genome structural variation, chromosomal aberrations and aneuploidy. Epimutations are defined as alterations in the epigenome, i.e., changes in DNA methylation, histone modification and small regulatory RNAs. We are interested in: mechanisms of (epi)mutation induction, for example, during DNA repair, replication or recombination; novel methods of (epi)mutation detection, with a focus on ultra-high-throughput sequencing; the landscape of somatic mutations and epimutations in cancer and aging; the role of de novo mutations in human disease and aging; mutations in population genomics; interactions between mutations and epimutations; the role of epimutations in chromatin structure and function; mitochondrial DNA mutations and their consequences in terms of human disease and aging; and novel ways to generate mutations and epimutations in cell lines and animal models. Of special interest are basic mechanisms through which DNA damage and mutations impact development and differentiation, stem cell biology and cell fate in general, including various forms of cell death and cellular senescence.

Sponsoring Association(s)

No associations affiliated with this journal

Publisher Name

Elsevier B.V.

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